Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation
نویسندگان
چکیده
منابع مشابه
Highly increased CSF tau protein and decreased â-amyloid (1–42) in sporadic CJD: a discrimination from Alzheimer’s disease?
The aim was to quantify tau protein and â-amyloid (Aâ42) in the CSF of patients with sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer’s disease (AD), and controls. Double sandwich enzyme linked immunosorbent assays (ELISAs) were used for measurments. Tau was increased 58-fold in CJD and 3.5-fold in AD compared with controls, whereas Aâ42 was decreased 0.5-fold in both CJD and AD. A cut oV le...
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The aim was to quantify tau protein and beta-amyloid (Abeta42) in the CSF of patients with sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD), and controls. Double sandwich enzyme linked immunosorbent assays (ELISAs) were used for measurements. Tau was increased 58-fold in CJD and 3.5-fold in AD compared with controls, whereas Abeta42 was decreased 0.5-fold in both CJD and AD. A...
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Alzheimer's disease is the most common form of dementia. Abnormal hyperphosphorylation of Microtubule associated protein tau (MAPT) is one of the hallmarks of Alzheimer's disease and related tau pathies. CDK5 and GSK3B are the two main protein kinases that have an important role in the abnormal hyperphosphorylation of MAPT which leads to Alzheimer's disease. Structural information for both MAPT...
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Alzheimer disease is a major cause of cognitive failure, and a pathogenically related but more subtle process accounts for many cases of mildmemory symptoms in older humans. Insoluble fibrillar plaques of amyloid β-proteins (Aβ) and neurofibrillary deposits of hyperphosphorylated tau proteins are the diagnostic lesions of AD, but their temporal mechanistic relationship has long been debated. Th...
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ژورنال
عنوان ژورنال: Alzheimer's Research & Therapy
سال: 2017
ISSN: 1758-9193
DOI: 10.1186/s13195-017-0317-z